Tribal colleges and universities (also known as TCUs), once overlooked, are growing in popularity as Native American (and some non-Native) students are increasingly recognizing the valuable opportunities provided by their local TCUs, including affordability. With increased student enrollment at these tribal institutions, the need and demand for culturally sensitive Title IX and Title VII investigations is growing as well. This insight paper, authored by Grand River Solutions Senior Investigator, LaNell Kay Shirley, offers considerations for conducting investigations in these communities.